CHAETOGLOBOSIN A Chemical Properties

Melting point:

188°C

Boiling point:

608.81°C (rough estimate)

Density 

1.1705 (rough estimate)

refractive index 

1.5800 (estimate)

storage temp. 

-20°C

solubility 

DMSO: soluble10mg/mL

form 

solid

pka

17.32±0.30(Predicted)

color 

Yellow

Stability:

Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Safety Information

WGK Germany 

3

HS Code 

2941900000

CHAETOGLOBOSIN A Usage And Synthesis

Description

Chaetoglobosin A (50335-03-0) is a cytochalasin analog which targets filamentous actin. Displays cytotoxic effects against human colorectal HCT116 cells, IC50=3.15 μM.1 Preferentially induces apoptosis in chronic lymphocytic leukemia cells via targeting the cytoskeleton.2 Enhances the fibrinolytic activity of vascular endothelial cells.3

Occurrence

A complex macrocyclic alkaloid, this base has been isolated from Diplodia rnacrospora. Chaetoglobosin A possesses the property of inhibiting growth in wheat coleoptiles.

Uses

Chaetoglobosin A is a mycotoxic cytochalasan compound.

Definition

ChEBI: A cytochalasan alkaloid isolated from Chaetomium globosum and Calonectria morganii.

storage

+4°C

References

1) Li et al. (2014), Chaetoglobosins from Chaetomium globosum, an endophytic fungus in Ginkgo biloba, and their phytotoxic and cytotoxic activities; J. Agric. Food Chem., 62 3734 2) Knudsen et al. (2014), Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton; Leukemia, 28 1289 3) Shinohara et al. (2000), Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B; J. Antibiot. (Tokyo), 53 262

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