5-(BENZYLTHIO)-N-METHYL-1,3,4-THIADIAZOL-2-AMINE
5-(BENZYLTHIO)-N-METHYL-1,3,4-THIADIAZOL-2-AMINE Basic information
- Product Name:
- 5-(BENZYLTHIO)-N-METHYL-1,3,4-THIADIAZOL-2-AMINE
- Synonyms:
-
- 5-(BENZYLTHIO)-N-METHYL-1,3,4-THIADIAZOL-2-AMINE
- MS21570
- ZERENEX E/5111275
- 1,3,4-thiadiazol-2-amine, N-methyl-5-[(phenylmethyl)thio]-
- N-Methyl-5-[(phenylmethyl)thio]-1,3,4-thiazadiazol-2-amine
- N-(5-benzylsulfanyl-[1,3,4]thiadiazol-2-yl)-methylamine
- Inhibitor,MS 21570,inhibit,MS21570,MS-21570
- MS21570, 10 mM in DMSO
- CAS:
- 65373-29-7
- MF:
- C10H11N3S2
- MW:
- 237.34
- Mol File:
- Mol File
5-(BENZYLTHIO)-N-METHYL-1,3,4-THIADIAZOL-2-AMINE Chemical Properties
- Boiling point:
- 389.6±35.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 125 mg/mL (526.67 mM)
- pka
- 2.67±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- InChI
- 1S/C10H11N3S2/c1-11-9-12-13-10(15-9)14-7-8-5-3-2-4-6-8/h2-6H,7H2,1H3,(H,11,12)
- InChIKey
- KFLNRVSOQJTXDG-UHFFFAOYSA-N
- SMILES
- [s]1c(nnc1NC)SCc2ccccc2
5-(BENZYLTHIO)-N-METHYL-1,3,4-THIADIAZOL-2-AMINE Usage And Synthesis
Uses
MS 21570, is a GPR171 antagonist. It reduces anxiety-like behavior and fear conditioning in mice.
Biological Activity
MS0021570 is a potent antagonist of GPR171, a G protein-coupled receptor of BigLEN (b-LEN), which is a neuropeptide derived from proSAAS and involved in regulation of feeding. MS0021570 had a IC50 value of 220 nM. It was shown to block inceases in food intake and to reduce anxiety-like behavior and fear conditioning in mice.
in vivo
MS21570 significantly attenuates this CNO-mediated increase in food intake. Interestingly, MS21570 causes a significant increase in center time compared to vehicle suggesting an effect on the anxiety-like behavior. Intra-BLA administration of MS21570 leads to an increase in open arm time on the elevated plus maze although there is no effect on locomotor activity during this test. Interestingly, when administered before and immediately following fear conditioning, MS21570 significantly attenuates freezing measured 24 hours later. Behavioral differences between systemic and intra-BLA administration of MS21570 could be due to the pharmacokinetic and pharmacodynamic properties of the drug. Further studies are needed to characterize the GPR171 antagonist[1].
storage
Store at -20°C
5-(BENZYLTHIO)-N-METHYL-1,3,4-THIADIAZOL-2-AMINESupplier
- Tel
- 15026594951
- rs@raise-chem.com
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
- Tel
- 15076683720
- klq@cw-bio.com
- Tel
- 571-89925085
- sales@amadischem.com
- Tel
- 021-61469567 13482353728
- sales@fdc-chemical.com