E-4031
E-4031 Basic information
- Product Name:
- E-4031
- Synonyms:
-
- 1-(2-(6-methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidined
- methanesulfonamide,n-(4-((1-(2-(6-methyl-2-pyridinyl)ethyl)-4-piperidinyl)carb
- E-4031
- N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride
- N-[4-[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinylcarbonyl]phenyl]methanesulfonamide·2hydrochloric acid
- E-4031 (hydrochloride)
- N-(4-(1-(2-(6-METHYLPYRIDIN-2-YL)ETHYL)PIPERIDINE-4-CARBONYL)PHENYL)METHANESULFONAMIDE 2HCL
- N-[4-[1-[2-(6-methylpyridin-2-yl)ethyl]piperidine-4-carbonyl]phenyl]methanesulfonamide dihydrochloride
- CAS:
- 113559-13-0
- MF:
- C21H33Cl2N3O5S
- MW:
- 510.47
- Product Categories:
-
- Potassium channel
- Ion Channels
- Mol File:
- 113559-13-0.mol
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E-4031 Chemical Properties
- storage temp.
- -20°C
- solubility
- H2O: soluble
- form
- solid
- color
- off-white
- Stability:
- Hygroscopic
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E-4031 Usage And Synthesis
Uses
E-4031 has been used as:
- human ether-a-go-go-related gene (hERG) blocker in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
- IKr blocker in long QT syndrome (LQTS) induced pluripotent stem (iPSCs) embryoid bodies
- IKr blocker in rat ventricular myocytes
Biological Activity
Selective blocker of hERG K + channels; inhibits the rapid delayed-rectifier K + current (I Kr ). Reversibly prolongs action potential duration in guinea pig papillary muscle and isolated ventricular myocytes, without affecting Na + or Ca 2+ inward currents. Class III antiarrhythmic agent.
Biochem/physiol Actions
E-4031 is a antiarrhythmic drug and belongs to the class III type. It is a methanesulfonanilide compound and is effective in treating arrhythmia and modulates ventricular fibrillation. E-4031 mediates the prolongation of action potential duration (APD) in transgenic long-QT type 1 (LQT1) rabbits. An isoleucine mutation in human ether-a-go-go-related gene (hERG) abolishes its interaction with E-4031.
storage
Room temperature (desiccate)
E-4031Supplier
J & K SCIENTIFIC LTD.
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
Ascent Scientific
- Tel
- 4401179829988
- customerservice@ascentscientific.co.uk
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
- Tel
- 025-66099280 17798518460
- cfzhang@aikonchem.com
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
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E-4031(113559-13-0)Related Product Information
- N-Methylbenzylamine
- N,N-DIETHYL-N-[2-(2-PYRIDYL)ETHYL]AMINE
- 4-BENZOYLPIPERIDINE HYDROCHLORIDE
- Betahistine dihydrochloride
- N-(4-ACETYL-PHENYL)-METHANESULFON-AMIDE
- E-4031,E-4031 DIHYDROCHLORIDE
- 4-(4-PIPERIDINYLMETHYL)-BENZENAMINE
- 4-(PHENYLMETHYL)-PIPERIDINE HYDROCHLORIDE
- 1-[2-(2-PYRIDYL)ETHYL]PIPERIDINE
- E-4031
- 2-(2'-AMINOETHYL)-6-METHYLPYRIDINE
- RARECHEM AL F1 4031
- AURORA KA-4031
- RARECHEM AK PP 4031
- AKOS BB-4031
- AURORA 4031
- E-4031, Voltage-Gated (HERG) K+ Channel Blocker, 510.48MW