2-(2-Aminoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide Chemical Properties

Boiling point:

486.2±45.0 °C(Predicted)

Density 

1.491±0.06 g/cm3(Predicted)

storage temp. 

Store at Room Tem.

pka

10.93±0.70(Predicted)

2-(2-Aminoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide Usage And Synthesis

Uses

HJC0152 (free base) is an orally active and potent inhibitor of STAT3. HJC0152 (free base) inhibits cell cycle progression and induces apoptosis. HJC0152 (free base) significantly suppresses MDA-MB-231 xenograft tumor growth in mice[1].

References

[1] Chen H, et al. Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents. ACS Med Chem Lett. 2013 Feb 14;4(2):180-185. DOI:10.1021/ml3003082