H-THR-PHE-ARG-GLY-ALA-PRO-OH
H-THR-PHE-ARG-GLY-ALA-PRO-OH Basic information
- Product Name:
- H-THR-PHE-ARG-GLY-ALA-PRO-OH
- Synonyms:
-
- PROTEINASE ACTIVATED RECEPTOR 3 (1-6) (HUMAN)
- PAR-3 (1-6) (HUMAN)
- TFRGAP
- THROMBIN RECEPTOR-LIKE 2 (1-6) (HUMAN)
- H-THR-PHE-ARG-GLY-ALA-PRO-OH
- COAGULATION FACTOR II RECEPTOR-LIKE 2 (1-6) (HUMAN)
- THR-PHE-ARG-GLY-ALA-PRO
- Coagulation Factor II Receptor-Like 2 (1-6) (huMan), Proteinase Activated Receptor 3 (1-6) (huMan), ThroMbin Receptor-Like 2 (1-6) (huMan), TFRGAP
- CAS:
- 320347-28-2
- MF:
- C29H45N9O8
- MW:
- 647.72
- Mol File:
- Mol File
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H-THR-PHE-ARG-GLY-ALA-PRO-OH Chemical Properties
- storage temp.
- -15°C
- solubility
- DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
- Sequence
- Thr-Phe-Arg-Gly-Ala-Pro
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H-THR-PHE-ARG-GLY-ALA-PRO-OH Usage And Synthesis
Uses
PAR3 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR3 and residues 39-44 of the full-length human sequence. PAR3 (1-6) activates p42/44 MAPK signaling in fibroblasts expressing PAR1, but not PAR3, an effect that can be blocked by the PAR1 antagonist RWJ 56110.
References
[1] Kaufmann, et al. Proteinase-activated receptors (PARs) - The PAR3 neo-N-terminal peptide TFRGAP interacts with PAR1. Regul. Pept. 125(1-3), 61-66 (2005).
H-THR-PHE-ARG-GLY-ALA-PRO-OHSupplier
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