HC-070
HC-070 Basic information
- Product Name:
- HC-070
- Synonyms:
-
- HC-070
- HC-070 (HC070)
- 1H-Purine-2,6-dione, 8-(3-chlorophenoxy)-7-[(4-chlorophenyl)methyl]-3,7-dihydro-1-(3-hydroxypropyl)-3-methyl-
- 7-(4-Chlorobenzyl)-8-(3-chlorophenoxy)-1-(3-hydroxypropyl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione
- HC-070, 10 mM in DMSO
- CAS:
- 1628291-95-1
- MF:
- C22H20Cl2N4O4
- MW:
- 475.32
- Mol File:
- 1628291-95-1.mol
HC-070 Chemical Properties
- Boiling point:
- 695.4±65.0 °C(Predicted)
- Density
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 62.5 mg/mL (131.49 mM)
- pka
- 14.85±0.10(Predicted)
- form
- Solid
- color
- White to off-white
HC-070 Usage And Synthesis
Description
HC-070 is a potent inhibitor of TRPC4 and TRPC5, leading to anxiolytic and antidepressant effects in mice.
Uses
HC-070 is an antagonist of TRPC4/TRPC5, with IC50s of 9.3 nM and 46 nM for hTRPC5 and hTRPC4 in cells, respectively.
in vivo
HC-070 (1 mg/kg, p.o.) affects mice with increased evoked anxiety (CCK-4), but shows no effects in the absence of CCK-4. HC-070 (0.3, 1 or 3 mg/kg, p.o.) decreases anxiety in a standard EPM (more light/high anxiety). HC-070 (1 mg/kg) reduces the increased capacity for fear memory in mice subjected to chronic social stress on days 1-15. In addition, HC-070 (1, 3, 10 mg/kg, p.o.) causes reduction in marble burying behavior. HC-070 (0.3, 1, 3, 10 mg/kg, p.o.) also reduces time of immobility in a tail suspension test but does not impact locomotor activity in mice[1].
References
[1] Just S, et al. Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice. PLoS One. 2018 Jan 31;13(1):e0191225. DOI:10.1371/journal.pone.0191225
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