14,15-LEUKOTRIENE A4 METHYL ESTER Chemical Properties

Boiling point:

442.5±45.0 °C(Predicted)

Density 

0.997±0.06 g/cm3(Predicted)

solubility 

Acetone: 30 mg/ml; DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml

14,15-LEUKOTRIENE A4 METHYL ESTER Usage And Synthesis

Description

14,15-Leukotriene A₄ (14,15-LTA₄) methyl ester is an esterified form of 14,15-LTA₄, a leukotriene isomer formed from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) by 15-lipoxygenase (15-LO) that inhibits LTA₄ hydrolase.

Uses

14,15-Leukotriene A4 methyl ester (14,15-LTA4 methyl ester) is the methyl esterified form of Leukotriene A4, which can be used for the study of biological effects of leukotrienes[1][2].

References

[1] Wetterholm A, et al. 14,15-Dihydroxy-5,8,10,12-eicosatetraenoic acid. Enzymatic formation from 14,15-leukotriene A4. Eur J Biochem. 1988 May 2;173(3):531-6. DOI:10.1111/j.1432-1033.1988.tb14031.x
[2] Rao A V R, et al. Enantiospecific synthesis of 14S, 15S leukotriene A4 methyl ester[J]. Bioorganic & Medicinal Chemistry Letters, 1991, 1(4): 201-204.