2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid
2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid Basic information
- Product Name:
- 2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid
- Synonyms:
-
- 2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid
- FAA1 agonist-1
- Acetic acid, 2-?[[4-?[(2'-?chloro[1,?1'-?biphenyl]?-?3-?yl)?methoxy]?phenyl]?sulfonyl]?-
- GPR40 agonist 4
- 2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfony...
- GPR-40 agonist 4,GPR40 agonist 4
- 2-[4-({2'-chloro-[1,1'-biphenyl]-3-yl}methoxy)benzenesulfonyl]acetic acid
- CAS:
- 2102196-57-4
- MF:
- C21H17ClO5S
- MW:
- 416.87
- Mol File:
- 2102196-57-4.mol
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2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid Chemical Properties
- Melting point:
- 121 - 123°C
- Boiling point:
- 644.4±55.0 °C(Predicted)
- Density
- 1.370±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly, Sonicated), Methanol (Slightly)
- form
- Solid
- pka
- 2.58±0.10(Predicted)
- color
- White to Off-White
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2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid Usage And Synthesis
Uses
2-[[4-[(2''-Chloro[1,1''-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic Acid, is a potent free fatty acid receptor 1 (FFA1/ GPR40) agonist with a pEC50 of 7.54.
in vivo
Single oral administration of GPR40 agonist 4 (compound 20) robustly reduces the plasma glucose excursion and enhances insulin secretion during an oral glucose tolerance test (OGTT) in a dose-dependent manner from 1 to 10 mg/kg when GPR40 agonist 4 is dosed 60 min prior to the oral glucose challenge. The area under the curve of blood glucose (AUC0-120min) and blood insulin (AUC0-120min) reveal that the minimum effective dose of GPR40 agonist 4 is 3 mg/kg. The hyperglycemia state is also markedly improved in GPR40 agonist 4 (20 mg/kg) treated group[1].
2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acidSupplier
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