(16(17)-DiHDPA
(16(17)-DiHDPA Basic information
- Product Name:
- (16(17)-DiHDPA
- Synonyms:
-
- (16(17)-DiHDPA
- (±)16(17)-DiHDPA MaxSpec? Standard
- 16,17-dihydroxy-4(Z),7(Z),10(Z),13(Z),19(Z)-docosapentaenoic acid
- 4,7,10,13,19-Docosapentaenoic acid, 16,17-dihydroxy-, (4Z,7Z,10Z,13Z,19Z)-
- CAS:
- 1345275-27-5
- MF:
- C22H34O4
- MW:
- 362.5
- Mol File:
- 1345275-27-5.mol
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(16(17)-DiHDPA Chemical Properties
- Boiling point:
- 537.8±50.0 °C(Predicted)
- Density
- 1.035±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.25 mg/ml
- pka
- 4.58±0.10(Predicted)
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(16(17)-DiHDPA Usage And Synthesis
Description
(±)16(17)-DiHDPA is produced from cytochrome P450 epoxygenase action on docosahexaenoic acid (DHA; ). It has been shown to inhibit VEGF-induced angiogenesis and reduce cancer cell metastasis in mice.1
Definition
ChEBI: 16,17-DiHDPE is a very long-chain fatty acid.
References
1. Zhang, G., Panigrahy, D., Mahakian, L.M., et al. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis Proc. Natl. Acad. Sci. USA 110(16),6530-6535(2013).
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