(16(17)-DiHDPA Chemical Properties

Boiling point:

537.8±50.0 °C(Predicted)

Density 

1.035±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.25 mg/ml

pka

4.58±0.10(Predicted)

(16(17)-DiHDPA Usage And Synthesis

Description

(±)16(17)-DiHDPA is produced from cytochrome P450 epoxygenase action on docosahexaenoic acid (DHA; ). It has been shown to inhibit VEGF-induced angiogenesis and reduce cancer cell metastasis in mice.¹

Uses

(±)16(17)-DiHDPA is a epoxygenase metabolite of docosahexaenoic acid (HY-B2167). (±)16(17)-DiHDPA inhibits platelet aggregation at concentrations below those affecting thromboxane synthesis[1][2].

Definition

ChEBI: 16,17-DiHDPE is a very long-chain fatty acid.

References

1. Zhang, G., Panigrahy, D., Mahakian, L.M., et al. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis Proc. Natl. Acad. Sci. USA 110(16),6530-6535(2013).