1--D-Glucosylsphingadienine (d18:2 (4E,8E))
1--D-Glucosylsphingadienine (d18:2 (4E,8E)) Basic information
- Product Name:
- 1--D-Glucosylsphingadienine (d18:2 (4E,8E))
- Synonyms:
-
- 1--D-Glucosylsphingadienine (d18:2 (4E,8E))
- β-D-Glucopyranoside, (2S,3R,4E,8E)-2-amino-3-hydroxy-4,8-octadecadienyl (9CI)
- 1-β-D-Glucosylsphingadienine (d18:2 (4E,8E))
- 1-β-D-Glucosylsphingadienine
- 2S-amino-3R-hydroxy-4E,8E-octadecadienyl,β-D-glucopyranoside
- CAS:
- 114200-59-8
- MF:
- C24H45NO7
- MW:
- 459.62
- Mol File:
- 114200-59-8.mol
1--D-Glucosylsphingadienine (d18:2 (4E,8E)) Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Chloroform:Methanol (4:1): Soluble
- form
- A solid
1--D-Glucosylsphingadienine (d18:2 (4E,8E)) Usage And Synthesis
Description
1-β-D-Glucosylsphingadienine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides (Item Nos. 23206 | 23207). They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells at concentrations of 10 and 50 μM, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner. Glucosylsphingosine levels are elevated in patients with Gaucher''s disease, both in the spleen (in types 1, 2, and 3) and brain (type 2 and 3); thus, glucosylsphingosine has been used as a key biomarker of the disease. This product contains 1-β-D-glucosylsphingadienine isolated from plants. [Matreya, LLC. Catalog No. 1310]
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