1--D-Glucosylsphingadienine (d18:2 (4E,8E)) Chemical Properties

storage temp. 

Store at -20°C

solubility 

Chloroform:Methanol (4:1): Soluble

form 

A solid

1--D-Glucosylsphingadienine (d18:2 (4E,8E)) Usage And Synthesis

Description

1-β-D-Glucosylsphingadienine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides (Item Nos. 23206 | 23207). They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells at concentrations of 10 and 50 μM, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner. Glucosylsphingosine levels are elevated in patients with Gaucher''s disease, both in the spleen (in types 1, 2, and 3) and brain (type 2 and 3); thus, glucosylsphingosine has been used as a key biomarker of the disease. This product contains 1-β-D-glucosylsphingadienine isolated from plants. [Matreya, LLC. Catalog No. 1310]