3-keto Sphinganine (d12:0) (hydrochloride) Chemical Properties

solubility 

Chloroform: soluble; Ethanol: soluble; Methanol: soluble

form 

A solid

3-keto Sphinganine (d12:0) (hydrochloride) Usage And Synthesis

Description

3-keto Sphinganine (d12:0) is a short-chain analog of the typical C18 chain-length 3-keto sphinganine (d18:0) . 3-keto Sphinganine (d18:0) is a lyso-sphingolipid formed by the condensation of L-serine and palmitoyl-CoA by serine palmitoyl transferase (SPT). Vitamin K deficiency inactivates SPT resulting in a decrease in the production of 3-keto sphinganine and other sphingolipids.¹

References

1. Batheja, A.D., Uhlinger, D.J., Carton, J.M., et al. Characterization of serine palmitoyltransferase in normal human tissues J. Histochem. Cytochem. 51(5),687-696(2003).