Sodium 4-Phenylbutyrate-d11 Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO: 25 mM,

form 

A solid

Water Solubility 

Water: 100 mM

Sodium 4-Phenylbutyrate-d11 Usage And Synthesis

Description

Sodium 4-Phenylbutyrate-d₁₁ is intended for use as an internal standard for the quantification of sodium 4-phenylbutyrate by GC- or LC-MS. Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins. It also weakly blocks histone deacetylase activity (IC₅₀ = 0.4 mM), which results in cell cycle arrest, differentiation, and/or apoptosis of various tumors. Formulations containing sodium 4-phenylbutyrate have been used for the treatment of urea cycle disorders.