C17 Lactosylceramide (d18:1/17:0) Chemical Properties

Boiling point:

995.4±65.0 °C(Predicted)

Density 

1.15±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

Chloroform:Methanol:Water (2:1:0.1): soluble

form 

A solid

pka

12.79±0.70(Predicted)

C17 Lactosylceramide (d18:1/17:0) Usage And Synthesis

Description

C17 Lactosylceramide is a naturally occurring sphingolipid that has been found in human brain metastases of lung adenocarcinomas but not in healthy brain tissue. [Matreya, LLC. Catalog No. 1538]

General Description

Lactosylceramide (LacCer) is a glycosphingolipid. It consists of a hydrophobic?ceramide?lipid and a hydrophilic sugar moiety. LacCer is expressed abundantly in the nervous system and myelin sheath.

Biochem/physiol Actions

Lactosylceramide (LacCer) is a structural and signaling lipid. It is implicated in signal transduction, cell adhesion and host-tissue pathogen interactions. LacCer modulates cell proliferation and apoptosis. It is involved in regulating cellular stress response and microbial pathogenesis. LacCer regulates innate immune responses. It helps in microbial attachment and also acts as an adhesion receptor for pathogens.