N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide Chemical Properties

Boiling point:

624.5±55.0 °C(Predicted)

Density 

0.997±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml

pka

9.79±0.10(Predicted)

N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide Usage And Synthesis

Description

N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide binds to the cannabinoid 1 (CB₁) receptor with a K_i value of 365 nM in a radioligand binding assay using rat brain homogenate.¹ It has an EC₅₀ value of 698 nM for the peroxisome proliferator-activated receptor α (PPARα) in a luciferase reporter assay and, in rats, it decreases food intake. It does not inhibit fatty acid amide hydrolase (FAAH).

References

1. Almeida, B., Joglar, J., Rojas, M.J.L., et al. Synthesis of fatty acid amides of catechol metabolites that exhibit antiobesity properties. ChemMedChem 4;5(10),1781-1787(2010).