GSK649A
GSK649A Basic information
- Product Name:
- GSK649A
- Synonyms:
-
- GSK649A
- GSK649A,GSK-649A
- Benzamide, 2-[[5-chloro-2-[(2-thiazolylmethyl)amino]-4-pyrimidinyl]amino]-6-fluoro-
- 2-((5-Chloro-2-((thiazol-2-ylmethyl)amino)pyrimidin-4-yl)amino)-6-fluorobenzamide
- CAS:
- 1848232-20-1
- MF:
- C15H12ClFN6OS
- MW:
- 378.81
- Mol File:
- 1848232-20-1.mol
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GSK649A Chemical Properties
- Boiling point:
- 564.1±60.0 °C(Predicted)
- Density
- 1.580±0.06 g/cm3(Predicted)
- pka
- 14.89±0.50(Predicted)
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GSK649A Usage And Synthesis
Description
GSK649A is a novel Activator of Satellite Cell Proliferation and Enhance Repair of Damaged Muscle.
Uses
GSK2226649A (compound 2) is a novel activator of satellite cell proliferation and enhanced repair of damaged muscle[1].
in vivo
The pharmacokinetic parameters of GSK2226649A(compound 2) in mice
| Dose(mg) | route | Cmax(ng/mL) | Tmax(hrs) | T1/2(hrs) | AUC0-inf(h*ng/mL) |
| 30 | oral | 1384 | 0.5 | 1.6 | 1720 |
| 30 | SC | 1783 | 1.0 | 6.1 | 12077 |
References
[1] Andrew N Billin, et al. Discovery of Novel Small Molecules that Activate Satellite Cell Proliferation and Enhance Repair of Damaged Muscle. ACS Chem Biol. 2016 Feb 19;11(2):518-29. DOI:10.1021/acschembio.5b00772
GSK649ASupplier
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
TargetMol Chemicals Inc.
- Tel
- 15002134094
- marketing@targetmol.cn
Biosynth Biological Technology (Suzhou) Co Ltd
- Tel
- 51288865780
- sales@biosynth.com
TargetMol Chemicals Inc.
- Tel
- +17819995354
- marketing@targetmol.com