Sphingosine Kinase Inhibitor, SKI-I Chemical Properties

Density 

1.33±0.1 g/cm3(Predicted)

solubility 

DMSO : 100 mg/mL (246.04 mM; Need ultrasonic)

pka

8.20±0.50(Predicted)

form 

Solid

color 

Off-white to light yellow

Sphingosine Kinase Inhibitor, SKI-I Usage And Synthesis

Uses

SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC50=11 μM). SKI-I induces apoptosis in tumor cell lines[1][2].

References

[1] French KJ, et, al. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003 Sep 15;63(18):5962-9. PMID:14522923
[2] Sharma AK, et, al. Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs. Eur J Med Chem. 2010 Sep;45(9):4149-56. DOI:10.1016/j.ejmech.2010.06.005