(R)-(-)-α-Methylhistamine dihydrobromide
(R)-(-)-α-Methylhistamine dihydrobromide Basic information
- Product Name:
- (R)-(-)-α-Methylhistamine dihydrobromide
- Synonyms:
-
- (R)-(-)-α-Methylhistamine dihydrobromide
- (αR)?-α-?Methyl-1H-?imidazole-?5-?ethanamine Hydrobromide
- (R)()αMethylhistamine dihydrobromide,(R) ( ) α Methylhistamine dihydrobromide
- CAS:
- 868698-49-1
- MF:
- C6H12BrN3
- MW:
- 206.09
- Mol File:
- 868698-49-1.mol
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(R)-(-)-α-Methylhistamine dihydrobromide Chemical Properties
- storage temp.
- Desiccate at RT
- form
- White solid.
- color
- Brown to reddish brown
- Water Solubility
- Soluble to 100 mM in water
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(R)-(-)-α-Methylhistamine dihydrobromide Usage And Synthesis
Uses
(αR)?-α-?Methyl-1H-?imidazole-?5-?ethanamine Hydrobromide is a histamine H3 agonist and an inhibitor of histamine synthesis.
in vivo
Pretreatment with (R)-(-)-α-Methylhistamine dihydrobromide (RAMH; 10 mg/kg; i.p.; 60 min before training) reverses Propofol‐induced (25 mg/kg; i.p.; 30 min before training) memory retention[5].
(R)-(-)-α-Methylhistamine dihydrochloride (6.3 mg/kg; i.p.) significantly decreases the steady-state t-MH level in the mouse brain, whereas these compounds produced no significant changes in the HA level[3].
| Animal Model: | Male Sprague‐Dawley rats (10-12 week)[3] |
| Dosage: | 10 mg/kg |
| Administration: | IP; 60 min before training |
| Result: | Reversed propofol‐induced memory retention. |
IC 50
H3 Receptor: 50.3 nM (Kd)
storage
Desiccate at RT
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