Ms-PEG8-t-butyl ester Chemical Properties

Boiling point:

625.3±55.0 °C(Predicted)

Density 

1.138±0.06 g/cm3(Predicted)

Ms-PEG8-t-butyl ester Usage And Synthesis

Description

Ms-PEG8-t-butyl ester is a PEG linker with a mesyl group and a t-butyl protecting group. Mesyl is a good leaving group and can participate in substitution reactions. The t-butyl group can be removed under acidic condtions. The hydrophilic PEG linker increases the solubility properties of compounds in aqueous media.

Uses

Ms-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005