stellettin B Chemical Properties

Boiling point:

620.4±55.0 °C(Predicted)

Density 

1.107±0.06 g/cm3(Predicted)

stellettin B Usage And Synthesis

Uses

Stellettin B is a triterpenoid compound that can be isolated from the marine sponge Jaspis stellifera. Stellettin B induces G1 phase arrest, apoptosis, and autophagy in human non-small cell lung cancer A549 cells by blocking the PI3K/Akt/mTOR pathway. Stellettin B can reduce the migration and invasion of liver cancer cells by decreasing the activation of the MAPK and FAK/PI3K/AKT/mTOR signaling pathways. Stellettin B can be used in the study of various tumors[1][2].

References

[1] Wang R, et al. Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway. Sci Rep. 2016 May 31;6:27071. DOI:10.1038/srep27071
[2] Tsai TC, et al. Stellettin B Isolated from Stelletta Sp. Reduces Migration and Invasion of Hepatocellular Carcinoma Cells through Reducing Activation of the MAPKs and FAK/PI3K/AKT/mTOR Signaling Pathways. Int J Cell Biol. 2022 Nov 29;2022:4416611. DOI:10.1155/2022/4416611