MW-150
MW-150 Basic information
- Product Name:
- MW-150
- Synonyms:
-
- MW-150 dihydrochloride dihydrate
- CAS:
- 1661020-92-3
- MF:
- C24H26ClN5O
- MW:
- 435.96
- Mol File:
- 1661020-92-3.mol
MW-150 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO : 20.83 mg/mL (42.47 mM)
MW-150 Usage And Synthesis
Uses
MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM. MW-150 dihydrochloride dihydrate (MW01-18-150SRM dihydrochloride dihydrate) inhibits the ability of the endogenous p38α MAPK to phosphorylate an endogenous substrate MK2 in activated glia[1].
in vivo
MW-150 dihydrochloride dihydrate (2.5 mg/kg; oral daily for 3 4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests[1].
MW-150 dihydrochloride dihydrate (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APPNLh/NLh × PSP264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice[1].
IC 50
p38α: 101 nM (Ki)
References
[1] Roy SM, et al. Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. ACS Chem Neurosci. 2015 Apr 15;6(4):666-80. DOI:10.1021/acschemneuro.5b00002
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