Fosamprenavir-d4 Usage And Synthesis

Uses

Fosamprenavir-d4 is deuterium labeled Fosamprenavir. Fosamprenavir (Amprenavir phosphate;GW 433908) is a phosphate ester proagent of the antiretroviral protease inhibitor Amprenavir, with improved solubility[1]. Anti-HIV infection[1].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Falcoz C, et al. Pharmacokinetics of GW433908, a prodrug of amprenavir, in healthy male volunteers. J Clin Pharmacol. 2002 Aug;42(8):887-98. DOI:10.1177/009127002401102803

Fosamprenavir-d4(1133702-41-6)Related Product Information

• Fosamprenavir Impurity 2
• AMPRENAVIR
• Fosamprenavir
• Fosamprenavir Impurity 1
• Fosamprenavir Impurity 3
• (S)-4-Chloro-1,3-butanediol
• tert-butyl ((2S,3S)-3-hydroxy-4-(isobutylamino)-1-phenylbutan-2-yl)carbamate