(S)-7-fluoro-6-(6-(methoxymethyl)pyridin-3-yl)-4-((1-(1-methyl-1H-pyrazol-3-yl)ethyl)amino)quinoline-3-carboxamide Chemical Properties

Boiling point:

631.4±55.0 °C(Predicted)

Density 

1.36±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

15.21±0.30(Predicted)

(S)-7-fluoro-6-(6-(methoxymethyl)pyridin-3-yl)-4-((1-(1-methyl-1H-pyrazol-3-yl)ethyl)amino)quinoline-3-carboxamide Usage And Synthesis

Uses

ATM Inhibitor-10 (compound 74), a 3-quinoline carboxamide, is a highly selective and orally active ATM inhibitor (IC50: 0.6 nM). ATM Inhibitor-10 has anti-tumor activity in SW620 xenograft models. ATM Inhibitor-10 is synergistic with Top I inhibitors[1].

storage

Store at -20°C

References

[1] Degorce SL, et al. Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase. J Med Chem. 2016 Jul 14;59(13):6281-92. DOI:10.1021/acs.jmedchem.6b00519