LY 367265
LY 367265 Basic information
- Product Name:
- LY 367265
- Synonyms:
-
- 1H,4H-[1,2,5]Thiadiazolo[4,3,2-ij]quinoline, 1-[2-[4-(6-fluoro-1H-indol-3-yl)-3,6-dihydro-1(2H)-pyridinyl]ethyl]-5,6-dihydro-, 2,2-dioxide
- CAS:
- 210751-39-6
- MF:
- C24H25FN4O2S
- MW:
- 452.54
- Mol File:
- 210751-39-6.mol
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LY 367265 Usage And Synthesis
Definition
ChEBI: LY-367,265 is a fluoroindole that is 1H-indole in which the hydrogens at positions 3 and 6 are replaced by 1-[2-(2,2-dioxo-5,6-dihydro-4H-2lambda(6)-[1,2,5]thiadiazolo[4,3,2-ij]quinolin-1(2H)-yl)ethyl]-1,2,3,6-tetrahydropyridin-4-yl and fluoro groups, respectively. It is an inhibitor of the 5-hydroxytryptamine transporter (Ki = 2.3 nM) and an antagonist of 5-hydroxytryptamine(2A) receptor (Ki = 0.81 nM). It has a role as an antidepressant, a serotonergic antagonist, a geroprotector and a serotonin uptake inhibitor. It is a fluoroindole, a dihydropyridine, a tertiary amino compound and a thiadiazoloquinoline.