TRANS-2 3-DIMETHOXY-BETA-NITROSTYRENE Chemical Properties

Melting point:

80-84 °C(lit.)

Boiling point:

328.3±27.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

storage temp. 

room temp

solubility 

DMSO: soluble15mg/mL (clear solution)

form 

powder

color 

faint yellow to dark yellow

Safety Information

Hazard Codes 

Xi,N

Risk Statements 

36-50/53

Safety Statements 

26-36-60-61

RIDADR 

UN 3077 9/PG 3

WGK Germany 

3

TRANS-2 3-DIMETHOXY-BETA-NITROSTYRENE Usage And Synthesis

Biochem/physiol Actions

CID 5380390 (trans-2,3-Dimethoxy-?-nitrostyrene) is a selective inhibitor of Protein Arginine Methyltransferases PRMT1 and PRMT8. PRMT1 is responsible for the majority of arginine methylation in the cell involved in transcription, chromatin modification, and signal transduction. CID 5380390 has an IC50 values of 23 μM for PRMT1, and does not inhibit PRMTs 3, 4, and 6, although it does inhibit PRMT8. The mechanism is believed to involve a specific S-adenosylmethionine (SAM)-binding cysteine present only in the Type I PRMTs PRMT1 and PRMT8 and absent in other SAM-dependent methyltransferases.

TRANS-2 3-DIMETHOXY-BETA-NITROSTYRENE(37630-20-9)Related Product Information

• 1,2-DIMETHOXY-3-(2-NITROVINYL)BENZENE
• 3,4-DIMETHOXY-B-NITROSTYRENE