3-FLUORO-5-METHOXYBENZOIC ACID 98 Chemical Properties

Melting point:

130-133

Boiling point:

278.4±20.0℃ (760 Torr)

Density 

1.307±0.06 g/cm3 (20 ºC 760 Torr)

Flash point:

122.2±21.8℃

storage temp. 

Sealed in dry,Room Temperature

form 

powder

pka

3.74±0.10(Predicted)

color 

White to off white

Safety Information

Hazard Codes 

Xi

Hazard Note 

Irritant/Keep Cold

HazardClass 

IRRITANT

HS Code 

2918999090

3-FLUORO-5-METHOXYBENZOIC ACID 98 Usage And Synthesis

Synthesis

The general procedure for the synthesis of 3-fluoro-5-methoxybenzoic acid from 3-fluoro-5-methoxybenzonitrile was as follows: in a 50 mL round-bottomed flask equipped with a magnetic stirrer and a reflux condenser tube, 3-fluoro-5-methoxybenzonitrile (0.62 g, 4.10 mmol), methanol (6.2 mL), and an aqueous sodium hydroxide solution (6.2 mL, 6 N) were added in sequence. The reaction mixture was stirred at 100 °C overnight. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. The concentrated residue was dissolved in dichloromethane (100 mL) and acidified to pH < 7 with aqueous 1 N hydrochloric acid. The organic phase was separated and washed sequentially with deionized water (100 mL) and saturated saline (100 mL). The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 3-fluoro-5-methoxybenzoic acid (0.64 g, 91% yield) as a white solid.

References

[1] Patent: US2003/55085, 2003, A1

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