LRRK2 inhibitor 1 Chemical Properties

Density 

1.347±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : 62.5 mg/mL (157.26 mM; Need ultrasonic)

form 

Solid

pka

13.00±0.50(Predicted)

color 

White to off-white

LRRK2 inhibitor 1 Usage And Synthesis

Uses

LRRK2 inhibitor 1 is a potent, selective and oral LRRK2 inhibitor with an pIC50 of 6.8.

References

[1] Ding X, et al. Discovery of 4-ethoxy-7H-pyrrolo[2,3-d]pyrimidin-2-amines as potent, selective and orally bioavailable LRRK2 inhibitors. Bioorg Med Chem Lett. 2018 May 15;28(9):1615-1620. DOI:10.1016/j.bmcl.2018.03.045