Propanoic acid, 3-(2-iodoethoxy)-, 1,1-dimethylethyl ester Chemical Properties

form 

Liquid

Propanoic acid, 3-(2-iodoethoxy)-, 1,1-dimethylethyl ester Usage And Synthesis

Description

tert-Butyl 3-(2-iodoethoxy)propanoate is a PEG reagent containing an iodine group and a t-butyl ester. The iodine (I) acts as a good leaving group for nucleophilic substitution reactions. The t-butyl ester groups can be deprotected under acidic conditions.

Uses

tert-Butyl 3-(2-iodoethoxy)propanoate is a PROTAC linker, which refers to the PEG composition. tert-Butyl 3-(2-iodoethoxy)propanoate can be used in the synthesis of PROTAC FAK degrader 1 (HY-119932)[1].

IC 50

PEGs

References

[1] Cromm PM, et al. Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation. J Am Chem Soc. 2018 Dec 12;140(49):17019-17026. DOI:10.1021/jacs.8b08008

Propanoic acid, 3-(2-iodoethoxy)-, 1,1-dimethylethyl ester(2296723-16-3)Related Product Information

• COOtBu-PEG10-I
• I-PEG4-t-Butyl ester
• Propanoic acid, 3-[2-[2-(2-iodoethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester
• COOtBu-PEG6-I
• COOtBu-PEG9-I
• COOtBu-PEG12-I
• tert-butyl 3-(2-(2-iodoethoxy)ethoxy)propanoate
• COOtBu-PEG5-I
• COOtBu-PEG8-I
• COOtBu-PEG11-I
• COOtBu-PEG7-I