4-(TRIFLUOROMETHYL)PIPERIDINE Chemical Properties

Melting point:

152-154°C

Boiling point:

126-129°C

Density 

1.129±0.06 g/cm3(Predicted)

refractive index 

1.3910 to 1.3950

storage temp. 

2-8°C(protect from light)

form 

Liquid

pka

9.62±0.10(Predicted)

color 

Colorless

InChI

InChI=1S/C6H10F3N/c7-6(8,9)5-1-3-10-4-2-5/h5,10H,1-4H2

InChIKey

RDRQUUWCJTYHCT-UHFFFAOYSA-N

SMILES

N1CCC(C(F)(F)F)CC1

Safety Information

Hazard Codes 

N

Risk Statements 

36/37/38-50

Safety Statements 

26-36/37/39-61

RIDADR 

2735

HazardClass 

8

PackingGroup 

Ⅲ

HS Code 

2933399990

4-(TRIFLUOROMETHYL)PIPERIDINE Usage And Synthesis

Uses

4-(Trifluoromethyl)piperidine is used in the preparation of retinoid-related orphan receptor inhibitors.

Synthesis

GENERAL STEPS: An autoclave (Par 477) equipped with PID temperature control and kinetic measurement storage and a HEL 24 Cat reactor for substrate range testing were used as the reactor for the hydrogenation reaction. In standard experiments, the autoclave was placed in a glove box and the desired Rh NPs (1.25 or 0.625 mol%; catalyst concentration was calculated based on the total number of metallic Rh atoms on the NP surface) and the substrate (concentration of 0.124 M in THF) were added. Subsequently, molecular hydrogen was passed until the set pressure was reached and the reaction was stirred at the selected temperature for the desired time. Upon completion of the reaction, the autoclave was depressurized and the solution was filtered through silica gel for subsequent GC analysis. The conversion and selectivity of each reaction product was determined by GC-FID on an Agilent Technologies 7890A spectrometer using undecane as an internal standard on an HP-5 column (30 m × 0.25 mm × 0.25 μm).The TOF (conversion frequency) was defined as the number of moles of product generated per mole of Rh per hour on the NP surface.

References

[1] Journal of Catalysis, 2017, vol. 354, p. 113 - 127

4-(TRIFLUOROMETHYL)PIPERIDINE(657-36-3)Related Product Information

• 4-(TRIFLUOROMETHYL)PIPERIDINE HYDROCHLO&,4-(TRIFLUOROMETHYL)PIPERIDINE HCL,4-(TRIFLUOROMETHYL)PIPERIDINE HYDROCHLORIDE
• 4-(TRIFLUOROMETHYL)PIPERIDINE
• 3-(TRIFLUOROMETHYL)PIPERIDINE,DL-3-(TRIFLUOROMETHYL)PIPERIDINE
• methyl 6-[4-(trifluoromethyl)piperidino]nicotinate
• Methyl 3-{[4-(trifluoromethyl)piperidin-1-yl]methyl}benzoate
• 5-nitro-2-[4-(trifluoromethyl)piperidino]benzenecarbaldehyde
• 6-[4-(trifluoromethyl)piperidino]nicotinic acid
• 3-{2-[4-(Trifluoromethyl)piperidin-1-yl]ethyl}benzaldehyde
• Methyl 4-{2-[4-(trifluoromethyl)piperidin-1-yl]ethoxy}benzoate
• ethyl 2-oxo-2-[4-(trifluoromethyl)piperidino]acetate
• 1-(5-nitro-2-pyridinyl)-4-(trifluoromethyl)piperidine
• 4-Amino-4-trifluoromethyl-piperidine-1-carboxylic acid benzyl ester
• 4-Aminomethyl-4-trifluoromethyl-piperidine-1-carboxylic acid tert-butyl ester
• 4-Trifluoromethyl-piperidine-4-carboxylic acid methyl ester
• 4-Aminomethyl-3-trifluoromethyl-piperidine-1-carboxylic acid tert-butyl ester
• ()-2-(TRIFLUOROMETHYL)PIPERIDINE
• 4-Amino-3-trifluoromethyl-piperidine-1-carboxylic acid benzyl ester
• 4-Trifluoromethyl-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester