OLDA Chemical Properties

Melting point:

60-61oC

Boiling point:

619.5±55.0 °C(Predicted)

Density 

1.004±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

DMSO: ~20 mg/mL, soluble

form 

powder

pka

9.79±0.10(Predicted)

color 

white

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

OLDA Usage And Synthesis

Uses

N-Oleoyldopamine is a bioactive lipid found in the mammalian brain that selectively activates the transient receptor potential vanilloid type 1 (TRPV1) channel. It is also a 5-lipoxygenase inhibitor.

Definition

ChEBI: N-oleoyldopamine is a fatty amide resulting from the formal condensation of the carboxy group of oleic acid with the amino group of dopamine. Synthesised in catecholaminergic neurons, it crosses the blood-brain barrier and might be considered as a carrier of dopamine into the brain. It is a transient receptor potential vanilloid type 1 (TRPV1) receptor agonist. It has a role as a TRPV1 agonist. It is a fatty amide, a secondary carboxamide, a member of catechols and a N-(fatty acyl)-dopamine. It is functionally related to a dopamine and an oleic acid.

Biological Activity

Potent endogenous vanilloid TRPV1 (VR1) receptor agonist (EC 50 = 36 nM at hVR1) with low affinity for rCB 1 receptors (K i = 1.6 μ M). Potently induces VR1-mediated thermal hyperalgesia in rats in vivo .

storage

Desiccate at -20°C

OLDA(105955-11-1)Related Product Information

• PSY-279
• IBTU
• JYL-273
• BCTC
• N-ETHYL-9Z-OCTADECENAMIDE
• OLDA
• Oleamide