1,2-DIAMINO-4,5-DIMETHOXYBENZENE Chemical Properties

Melting point:

134-135℃

Boiling point:

329.0±37.0 °C(Predicted)

Density 

1.184

storage temp. 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

pka

4?+-.0.10(Predicted)

form 

Solid

color 

Brown to black

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HS Code 

2922290090

1,2-DIAMINO-4,5-DIMETHOXYBENZENE Usage And Synthesis

Uses

1,2-Diamino-4,5-dimethoxybenzene reacts with aldehydes to produce highly fluorescent benzimidazole derivatives. It can be used for the detection of aromatic aldehydes as well as DTAN.

Synthesis

1,2-Dimethoxy-4,5-dinitrobenzene (5 g, 21.9 mmol) was used as starting material and dissolved in methanol (147 ml). Subsequently, 10% Pd/C catalyst (639 mg) was added to the solution. The reaction was stirred for 6 h at room temperature under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated under reduced pressure. The resulting residue gave 4,5-dimethoxy-1,2-phenylenediamine (compound 28) directly without further purification.

References

[1] Patent: KR101840674, 2018, B1. Location in patent: Paragraph 0684-0686
[2] RSC Advances, 2016, vol. 6, # 30, p. 25203 - 25214
[3] Journal of Medicinal Chemistry, 1993, vol. 36, # 3, p. 331 - 342
[4] European Journal of Organic Chemistry, 2011, # 28, p. 5427 - 5440
[5] Chemistry - A European Journal, 2017, vol. 23, # 41, p. 9888 - 9896

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