S-(4-NITROBENZYL)-6-THIOINOSINE
S-(4-NITROBENZYL)-6-THIOINOSINE Basic information
- Product Name:
- S-(4-NITROBENZYL)-6-THIOINOSINE
- Synonyms:
-
- S-(P-NITROBENZYL)-6-THIOINOSINE
- S-(4-NITROBENZYL)-6-THIOINOSINE
- NBMPR
- NBTI
- 4-nitrobenzylthioinosine
- 6-(((4-nitrophenyl)methyl)thio)-9-beta-d-ribofuranosyl-9h-purin
- 6-(((4-nitrophenyl)methyl)thio)-9-beta-d-ribofuranosyl-9h-purine
- 6-(p-nitrobenzylthio)inosine
- CAS:
- 38048-32-7
- MF:
- C17H17N5O6S
- MW:
- 419.41
- EINECS:
- 253-753-4
- Product Categories:
-
- Bases & Related Reagents
- Heterocycles
- Inhibitors
- Nucleotides
- Sulfur & Selenium Compounds
- Mol File:
- 38048-32-7.mol
S-(4-NITROBENZYL)-6-THIOINOSINE Chemical Properties
- Melting point:
- 187-190 °C(lit.)
- Boiling point:
- 770.2±70.0 °C(Predicted)
- Density
- 1.3904 (rough estimate)
- refractive index
- 1.6460 (estimate)
- storage temp.
- 2-8°C
- solubility
- 0.1 M HCl: slightly soluble
- form
- solid
- pka
- 13.08±0.70(Predicted)
- color
- white
- CAS DataBase Reference
- 38048-32-7(CAS DataBase Reference)
Safety Information
- Safety Statements
- 24/25
- WGK Germany
- 3
- RTECS
- UO9025000
- HS Code
- 29349990
MSDS
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
S-(4-NITROBENZYL)-6-THIOINOSINE Usage And Synthesis
Chemical Properties
Off-White Solid
Uses
It is a prototype inhibitor of the human equilibrative nucleoside transporter (hENT1), and is a high affinity ligand with a Kd of 0.1-1.0 nM. Nucleoside transporter inhibitors have potential therapeutic applications as anticancer, antiviral, cardio
Uses
S-(4-Nitrobenzyl)-6-thioinosine is a nucleoside analog and an inhibitor of the human equilibrative nucleoside transporter (hENT1) (1,2,3). Nucleoside transporter inhibitors are useful compounds to investigate anticancer, antiviral, cardioprotective, and neuroprotective agents.
Definition
ChEBI: NBMPR is a purine nucleoside.
General Description
S-(4-Nitrobenzyl)-6-thioinosine (NBTI) belongs to the family of S6-substituted 6-thiopurine nucleosides, which regulate nucleoside transport mechanisms in animals. It acts as a ligand of adenosine transporter. Binding sites for NBTI is located on brain capillaries. It functions as a covalent photoaffinity probe for nucleoside transport.
Biological Activity
Equilibrative nucleoside transporter 1 (ENT1) inhibitor (K i values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).
Biochem/physiol Actions
Inhibitor of equilibrative nucleoside transporters (ENTs), particularly adenosine transporters, in central nervous system and vascular smooth muscle.
storage
Store at +4°C
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