1-BENZYL-3-(TERT-BUTYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID Chemical Properties

Melting point:

126 °C

Boiling point:

438.4±40.0 °C(Predicted)

Density 

1.12±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

form 

Solid

pka

3.69±0.36(Predicted)

color 

White to off-white

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-36

Safety Statements 

26-36/37/39

Hazard Note 

Irritant

1-BENZYL-3-(TERT-BUTYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID Usage And Synthesis

Uses

SORT-PGRN interaction inhibitor 1 is a potent inhibitor of the sortilin-progranulin interaction with an IC50 of 2 μM[1].

References

[1] Shawn J Stachel, et al. Identification of potent inhibitors of the sortilin-progranulin interaction. Bioorg Med Chem Lett. 2020 Sep 1;30(17):127403. DOI:10.1016/j.bmcl.2020.127403

1-BENZYL-3-(TERT-BUTYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID(100957-85-5)Related Product Information

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• 3-(TERT-BUTYL)-1-(3-METHYLBENZYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID
• ETHYL 3-(TERT-BUTYL)-1-(2,4-DICHLOROBENZYL)-1H-PYRAZOLE-5-CARBOXYLATE
• 3-(TERT-BUTYL)-1-(MESITYLMETHYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID
• 3-(TERT-BUTYL)-1-(4-FLUOROBENZYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID
• ETHYL 3-TERT-BUTYL-1-(2,4,6-TRIMETHYLBENZYL)-1H-PYRAZOLE-5-CARBOXYLATE
• ETHYL 3-(TERT-BUTYL)-1-(3-METHYLBENZYL)-1H-PYRAZOLE-5-CARBOXYLATE
• ETHYL 1-BENZYL-3-(TERT-BUTYL)-1H-PYRAZOLE-5-CARBOXYLATE
• 3-(TERT-BUTYL)-1-(2,4-DICHLOROBENZYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID
• 1-BENZYL-3-(TERT-BUTYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID