9(R)-HETE
9(R)-HETE Basic information
- Product Name:
- 9(R)-HETE
- Synonyms:
-
- 9(R)-HETE
- 9R-HYDROXY-5Z,7E,11Z,14Z-EICOSATETRAENOIC ACID
- 9(R)-hydroxy-(5Z,7E,11Z,14Z)-*eicosatetraenoic ac
- KATOYYZUTNAWSA-AZFZJQGOSA-N
- 5,7,11,14-Eicosatetraenoic acid, 9-hydroxy-, (5Z,7E,9R,11Z,14Z)-
- 9(R) HETE,9(R)HETE
- 9(R)-hydroxy-5(Z),7(E),11(Z),14(Z)-ETA
- CAS:
- 107656-14-4
- MF:
- C20H32O3
- MW:
- 320.47
- Mol File:
- 107656-14-4.mol
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9(R)-HETE Chemical Properties
- Boiling point:
- 487.7±33.0 °C(Predicted)
- Density
- 0.984±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml
- pka
- 4.73±0.10(Predicted)
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9(R)-HETE Usage And Synthesis
Uses
9(R)-HETE is an enantiomer which makes up 50% of (±)9-HETE. At a concentration of 300 nM, 9(R)-HETE activates RXRγ-dependent transcription 1.5 fold relative to a control.1 Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
Definition
ChEBI: 9R-HETE is a polyunsaturated fatty acid and a hydroxy fatty acid.
References
[1] Eager, et al. Structural and functional evidence for activation of a chick retinoid X receptor by eicosanoids. Proc. Biol. Sci. 250(1327), 63-69 (1992).
9(R)-HETESupplier
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