2,5-Dibromo-4-methylimidazole Chemical Properties

Boiling point:

343.1±34.0 °C(Predicted)

Density 

2.188±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

9.47±0.10(Predicted)

Appearance

Off-white to light yellow Solid

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HS Code 

2933299090

2,5-Dibromo-4-methylimidazole Usage And Synthesis

Synthesis

General procedure for the synthesis of 2,5-dibromo-4-methylimidazole from 4-methylimidazole: 4-methylimidazole (3.4 g, 40 mmol) was dissolved in tetrahydrofuran (THF, 50 mL) at room temperature. Subsequently, N-bromosuccinimide (NBS, 14 g, 80 mmol) was added to this solution. The reaction mixture was stirred for 1 hour. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography (eluent ratio: petroleum ether (PE):ethyl acetate (EA) = 2:1) to afford 2,5-dibromo-4-methylimidazole (9.6 g, 99% yield) as a white solid. Mass spectrometry (ESI-MS) analysis showed: m/z 239.0 [M + H]+.

References

[1] Patent: WO2015/26792, 2015, A1. Location in patent: Paragraph 0229

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