Sodium hydroxymethanesulphinate Chemical Properties

Melting point:

~120 °C (dec.)

Density 

1.744[at 20℃]

vapor pressure 

0.003Pa at 20℃

Flash point:

>100℃

storage temp. 

Inert atmosphere,Room Temperature

solubility 

H₂O: 50 mg/mL, clear, colorless

form 

Solid

color 

White to Off-White

PH

9.5-10.5

Water Solubility 

soluble H2O, alcohol [HAW93]

Merck 

14,8620

Stability:

Stable. Incompatible with strong oxidizing agents.

LogP

-3.4 at 22℃

EPA Substance Registry System

Sodium sulfoxylate formaldehyde (anhydrous) (149-44-0)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-68-31

Safety Statements 

26-36-36/37

WGK Germany 

1

RTECS 

PB0380000

TSCA 

Yes

HS Code 

2930909899

Hazardous Substances Data

149-44-0(Hazardous Substances Data)

Sodium hydroxymethanesulphinate Usage And Synthesis

Chemical Properties

white solid; used as stripping and discharge agent for textiles [HAW93]

Chemical Properties

When freshly prepared, sodium formaldehyde sulfoxylate occurs as white, odorless crystals, which quickly develop a characteristic garlic odor on standing.

Uses

Pharmaceutic aid (preservative).

Uses

Sodium Hydroxymethanesulfinate Hydrate is the hydrated version of Sodium Hydroxymethanesulfinate (S634950), which is an organic reductant that is stable in alkaline enviroments but readily decomposes in acidic medium to produce a number of products, one of them being sulfur dioxide. Sodium hydroxymethanesulfinate is also used in conjunction with substituted anilines (e.g. p-Anisidine [A673505]) to synthesize anilinomethanesulfonates.

Production Methods

Sodium formaldehyde sulfoxylate is manufactured from sodium dithionate and formaldehyde in water.

Flammability and Explosibility

Non flammable

Pharmaceutical Applications

Sodium formaldehyde sulfoxylate is a water-soluble antioxidant and is generally used as the dihydrate. It is used in the formulation of injection products at a level of up to 0.1% w/v in the final preparation administered to the patient.

Safety

The toxicological properties of sodium formaldehyde sulfoxylate have not been fully investigated. However, it is used in the formulation of injection products at a level to 0.1% w/v in the final preparation administered to the patient.
Sodium formaldehyde sulfoxylate is moderately toxic by ingestion, and when heated to decomposition it emits toxic fumes of sulfur dioxide and sodium oxide.
LD50 (mouse, oral): 4 g/kg
LD50 (rat, IP): >2 g/kg
LD50 (rat, oral): >2 g/kg

storage

Store in well-closed, light-resistant containers at controlled room temperature (15–30℃).

Purification Methods

It crystallises from H2O as the dihydrate and decomposes at higher temperatures. Store it in a closed container in a cool place. It is insoluble in EtOH and Et2O and is a good reducing agent. [X-ray structure: Tuter J Chem Soc 3064 1955.] Note that this compound {HOCH2SO2Na} should not be confused with formaldehyde sodium bisulfite adduct {HOCH2SO3Na} from which it is prepared by reduction with Zn. [Beilstein 1 IV 3052.]

Incompatibilities

Sodium formaldehyde sulfoxylate is incompatible with strong oxidizing agents; it is decomposed by dilute acid.

Regulatory Status

Included in the FDA Inactive Ingredients Database (parenteral products up to 0.1% via the IM, IV, and SC routes). Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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