4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1-PROPYL-1H-PURIN-8-YL)-BENZENESULFONIC ACID
4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1-PROPYL-1H-PURIN-8-YL)-BENZENESULFONIC ACID Basic information
- Product Name:
- 4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1-PROPYL-1H-PURIN-8-YL)-BENZENESULFONIC ACID
- Synonyms:
-
- 4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1-PROPYL-1H-PURIN-8-YL)-BENZENESULFONIC ACID
- 4-(2,6-Dioxo-1-propyl-2,3,6,7-tetrahydro-1H-purin-8-yl)benzenesulfonic acid
- BENZENESULFONIC ACID,4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1-PROPYL-1H-PURIN-8-YL)-
- Benzenesulfonic acid, 4-(2,3,6,9-tetrahydro-2,6-dioxo-1-propyl-1H-purin-8-yl)-
- 4-(2,6-Dioxo-1-propyl-2,3,6,9-tetrahydro-1H-purin-8-yl)benzenesulfonic acid
- CAS:
- 152529-79-8
- MF:
- C14H14N4O5S
- MW:
- 350.35
- Product Categories:
-
- Adenosine receptor
- Mol File:
- 152529-79-8.mol
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4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1-PROPYL-1H-PURIN-8-YL)-BENZENESULFONIC ACID Chemical Properties
- Melting point:
- >300 °C
- Density
- 1.522±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C, protect from light
- solubility
- Soluble to 100 mM in DMSO and to 20 mM in water with gentle warming
- form
- Powder
- pka
- -1.59±0.50(Predicted)
- color
- Off-white to light brown
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4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1-PROPYL-1H-PURIN-8-YL)-BENZENESULFONIC ACID Usage And Synthesis
Uses
PSB-1115 is a selective A2B Adenosine Receptor antagonist. PSB-1115 inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh)[1].
Definition
ChEBI: 4-(2,6-dioxo-1-propyl-3,7-dihydropurin-8-yl)benzenesulfonic acid is an oxopurine.
in vivo
PSB-1115 (0.5 mg/kg; i.p.; single dose, injected 20 minutes before inhalation) antagonizes the inhibitory effect of the non-selective adenosine receptor agonist NECA (HY-103173) on mucociliary clearance in mice[2].
IC 50
A2BR
storage
Store at RT
References
[1] Michael S, et al. Adenosine A(2A) agonist and A(2B) antagonist mediate an inhibition of inflammation-induced contractile disturbance of a rat gastrointestinal preparation. Purinergic Signal. 2010 Mar;6(1):117-24. DOI:10.1007/s11302-009-9174-y
4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1-PROPYL-1H-PURIN-8-YL)-BENZENESULFONIC ACIDSupplier
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4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1-PROPYL-1H-PURIN-8-YL)-BENZENESULFONIC ACID(152529-79-8)Related Product Information
- Benzenesulfonic acid
- 4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1-PROPYL-1H-PURIN-8-YL)-BENZENESULFONIC ACID POTASSIUM SALT
- PSB 1115 POTASSIUM SALT
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