10,10-BIS[(2-FLUORO-4-PYRIDINYL)METHYL]-9(10H)-ANTHRACENONE Chemical Properties

Melting point:

159-161 °C

Boiling point:

593.1±50.0 °C(Predicted)

Density 

1.319±0.06 g/cm3(Predicted)

storage temp. 

Store at RT

solubility 

Soluble to 100 mM in DMSO and to 50 mM in ethanol

form 

Powder

pka

0.38±0.10(Predicted)

color 

White to yellow

10,10-BIS[(2-FLUORO-4-PYRIDINYL)METHYL]-9(10H)-ANTHRACENONE Usage And Synthesis

Uses

DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer[1][2].

Definition

ChEBI: 10,10-bis[(2-fluoro-4-pyridinyl)methyl]-9-anthracenone is a member of anthracenes.

References

[1] Ipavec V, et al. KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus. Pharmacol Res. 2011 Oct;64(4):397-409. DOI:10.1016/j.phrs.2011.06.016
[2] Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30. PMID:9580619

10,10-BIS[(2-FLUORO-4-PYRIDINYL)METHYL]-9(10H)-ANTHRACENONE(160588-45-4)Related Product Information

• 5-Fluorouracil
• 2-Chloro-5-trifluoromethylpyridine
• DI-2-PYRIDYL KETONE
• 4-Isopropylpyridine
• Anthrone
• 4-phenethylpyridine
• 4-ISOBUTYL-PYRIDINE
• 2-Fluoro-4-methylpyridine
• 10,10-Dimethylanthrone
• 4,4'-Trimethylenedipyridine
• 10,10-BIS[(2-FLUORO-4-PYRIDINYL)METHYL]-9(10H)-ANTHRACENONE