dextilidine
dextilidine Basic information
- Product Name:
- dextilidine
- Synonyms:
-
- dextilidine
- 2α-(Dimethylamino)-1-phenyl-3-cyclohexene-1β-carboxylic acid ethyl ester
- 2α-(Dimethylamino)-1α-phenyl-3-cyclohexene-1β-carboxylic acid ethyl ester
- (1R,2R)-2-(Dimethylamino)-1-phenyl-3-cyclohexene-1-carboxylic acid ethyl ester
- (1S,2S)-2-(Dimethylamino)-1-phenyl-3-cyclohexene-1-carboxylic acid ethyl ester
- 3-Cyclohexene-1-carboxylic acid, 2-(dimethylamino)-1-phenyl-, ethyl ester, (1S,2R)-
- CAS:
- 32447-90-8
- MF:
- C17H23NO2
- MW:
- 273.37
- EINECS:
- 251-048-6
- Mol File:
- 32447-90-8.mol
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dextilidine Chemical Properties
- Melting point:
- 56-58 °C
- Boiling point:
- 354.2±42.0 °C(Predicted)
- Density
- 1.06±0.1 g/cm3(Predicted)
- pka
- 8.26±0.40(Predicted)
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dextilidine Usage And Synthesis
Definition
ChEBI: Dextilidine is an ethyl 2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate that has S configuration at the carbon bearing the phenyl group and R configuration at the carbon bearing the dimethylamino group. The opioid analgesic tilidine is the racemate comprising equimolar amounts of dextilidine and its enantiomer, ent-dextilidine. A prodrug, tilidine is converted by the liver to the active analgesic, nortilidine; virtually all of the opioid activity resides in the (1S,2R) isomer (i.e. the isomer derived from dextilidine). It has a role as an opioid analgesic and a prodrug. It is an enantiomer of an ent-dextilidine.