MRTX1133
MRTX1133 Basic information
- Product Name:
- MRTX1133
- Synonyms:
-
- 2-Naphthalenol, 4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-
- MRTX1133
- 4-(4-(3,8-Diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol
- 4-[4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-[[(2S,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoronaphthalen-2-ol
- KRAS,Ras,MRTX 1133,G12D,cells,active,wild-type,phosphorylation,mutant,MRTX1133,inactive,ERK,inhibit,tumor,states,MRTX-1133,Inhibitor
- 4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-2-Naphthalenol
- CAS:
- 2621928-55-8
- MF:
- C33H31F3N6O2
- MW:
- 600.63
- Mol File:
- 2621928-55-8.mol
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MRTX1133 Chemical Properties
- Density
- 1.49±0.1 g/cm3(Predicted)
- solubility
- DMSO:50.0(Max Conc. mg/mL);83.24(Max Conc. mM)
- form
- A solid
- pka
- 8.05±0.40(Predicted)
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MRTX1133 Usage And Synthesis
Uses
MRTX1133 is a potent and selective KRAS G12D inhibitor that targets KRAS G12D protein in both the active and inactive states. In preclinical studies, MRTX1133 exhibited a long half-life, was able to bind to KRAS G12D protein in both active and inactive states, and selectively inhibited KRAS G12D-mutated cancer cells. In G12D mutant tumor models, it showed dose-dependent selective inhibition of the KRAS pathway and tumor regression.
Chemical Properties
Solid powder.
storage
Dry, dark and at 0-4℃ for short term (days to weeks) or -20℃ for long term (months to years).
MRTX1133Supplier
Nantong Hi-Future Biotechnology Co., Ltd Gold
- Tel
- 18051384581
- sales@chemhifuture.com
ShangHai Biochempartner Co.,Ltd Gold
- Tel
- 17754423994 17754423994
- 2853530910@QQ.com
Changzhou Chenhong Biotechnology Co., Ltd. Gold
- Tel
- 0519-85788828 13775037613
- sales@chemrenpharm.com
Changzhou Borl Biotechnology Co.,LTD Gold
- Tel
- 13606124132;13656121842
- luyan0021@163.com
Wuxi Donghe Pharmaceutical Technology Co., Ltd. Gold
- Tel
- 63313187 15358055255
- 63313187@qq.com