tetroxoprim
tetroxoprim Basic information
- Product Name:
- tetroxoprim
- Synonyms:
-
- 2,4-Diamino-5-[3,5-dimethoxy-4-(2-methoxyethoxy)benzyl]pyrimidine
- 5-[[3,5-Dimethoxy-4-(2-methoxyethoxy)phenyl]methyl]-2,4-pyrimidinediamine
- 5-[3,5-Dimethoxy-4-(2-methoxyethoxy)benzyl]-2,4-pyrimidinediamine
- 5-[3,5-Dimethoxy-4-(2-methoxyethoxy)benzyl]pyrimidine-2,4-diamine
- tetroxoprim
- 2,4-Pyrimidinediamine, 5-[[3,5-dimethoxy-4-(2-methoxyethoxy)phenyl]methyl]-
- 5-[[3,5-dimethoxy-4-(2-methoxyethoxy)phenyl]methyl]pyrimidine-2,4-diamine
- HE 781
- CAS:
- 53808-87-0
- MF:
- C16H22N4O4
- MW:
- 334.37
- EINECS:
- 258-789-4
- Mol File:
- 53808-87-0.mol
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tetroxoprim Chemical Properties
- Melting point:
- 153-156° (Liebenow, Prikryl); mp 160.1° (eidem, J. Antimicrob. Chemother. 5, Suppl B, 15 (1979))
- Boiling point:
- 564.1±60.0 °C(Predicted)
- Density
- 1.232±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light, stored under nitrogen
- solubility
- DMSO : 16.67 mg/mL (49.85 mM; ultrasonic and warming and heat to 60°C)
- pka
- pKb 8.25(at 25℃)
- form
- Solid
- color
- White to off-white
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tetroxoprim Usage And Synthesis
Uses
Tetroxoprim is an antimicrobial DHFR inhibitor[1].
Definition
ChEBI: Tetroxoprim is a dimethoxybenzene.
References
[1] H S Aschhoff, et al. Tetroxoprim--a new inhibitor of bacterial dihydrofolate reductase. J Antimicrob Chemother. 1979 Nov;5(B):19-25. DOI:10.1093/jac/5.supplement_b.19
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