Basic information Safety Supplier Related

bufeniode

Basic information Safety Supplier Related

bufeniode Basic information

Product Name:
bufeniode
Synonyms:
  • bufeniode
  • Diiodobuphenine
  • 4-[1-Hydroxy-2-(1-methyl-3-phenylpropylamino)propyl]-2,6-diiodophenol
  • Bufeniod
  • HF-241
  • Proclival
CAS:
22103-14-6
MF:
C19H23I2NO2
MW:
551.196
EINECS:
244-781-8
Mol File:
22103-14-6.mol
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bufeniode Chemical Properties

Melting point:
(slow heating) 185° (dec); mp (fast heating) 212°
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Safety Information

Toxicity
LD50 in mice: >600 mg/kg i.p., >2 g/kg orally (Fourneau, Delourme)
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bufeniode Usage And Synthesis

Originator

Proclival,Houde,France,1970

Definition

ChEBI: Bufeniode is an alkylbenzene.

Manufacturing Process

Buphenine is the starting material. See under the alternative name "Nylidrin" in this publication for synthesis.
24 grams of buphenine hydrochloride are suspended in a mixture of 440 ml of 34% ammonia (specific gravity = 0.89) and 315 ml of water. 41 grams of iodine dissolved in 1,080 ml of 96% alcohol are added little by little, with good stirring. During this addition, effected in about 30 min, buphenine hydrochloride dissolves fairly rapidly, and then the diiodobuphenine precipitates out as a crystalline powder. Stirring is continued for a further hour. The precipitate is suction filtered, and then washed with water, with alcohol and with ether and is finally dried in vacuo in the exsiccator in the presence of phosphoric anhydride. Thus, about 23 grams of diiodobuphenine solvated with 1 mol of ethanol are obtained in the form of a microcrystalline white powder. MP (slow) = 185°C (dec.). MP (inst.): 212°C.

Therapeutic Function

Antihypertensive

bufeniodeSupplier

Shaanxi Dideu Newmaterial Co., Ltd.
Tel
029-87576359 15353716720
Email
1039@dideu.com
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bufeniode(22103-14-6)Related Product Information