4-isobutyloxazolidine-2,5-dione Chemical Properties

Melting point:

47-48 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4))

Density 

1.124±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

9.38±0.40(Predicted)

Safety Information

HS Code 

2934999090

4-isobutyloxazolidine-2,5-dione Usage And Synthesis

Preparation

A solution of phosgene(12.5% in toluene, 25 mL, 31.6 mmol) was added to a suspension of l-leucine (1.31 g, 10 mmol) in dioxane (30 mL) and ethyl acetate (25 mL) at 40 ℃ under a static atmosphere of nitrogen. After 4 h, the leucine had dissolved and then the excess phosgene was removed in a stream of nitrogen. The solvent was removed at 40 ℃ in vacuo and the residue was recrystallized from diethyl ether/light petroleum (bp 40–60 ℃) to yield colorless needles of 4-(2-methylpropyl)oxazolidine-2,5-dione (1.01 g, 69%).