vinconate
vinconate Basic information
- Product Name:
- vinconate
- Synonyms:
-
- vinconate
- Vintenate
- Chanodesethylapovinc?amine
- Vincote
- 1H-Indolo[3,2,1-de][1,5]naphthyridine-6-carboxylic acid, 3-ethyl-2,3,3a,4-tetrahydro-, methyl ester
- CAS:
- 70704-03-9
- MF:
- C18H20N2O2
- MW:
- 296.368
- EINECS:
- 2747897
- Mol File:
- 70704-03-9.mol
vinconate Chemical Properties
- Melting point:
- 120-121°
- Boiling point:
- 363.6±42.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 8.00±0.40(Predicted)
vinconate Usage And Synthesis
Uses
Vinconate is an indolonaphthyridine derivative and can stimulate the muscariic acetylcholine receptor.
in vivo
Treatment with Vinconate (50 to 200 mg/kg p.o.) significantly increases dopamine concentrations in dialysate. Daily treatment with Vinconate (25 mg/kg) for 7 days also significantly increases dopamine and serotonin concentrations in dialysate[1]. Chronic treatment with Vinconate at a 10 mg/kg significantly ameliorats the reduction in [3H]QNB binding in the nucleus accumbens and cerebellum. Furthermore, this Vinconate treatment significantly enhances [3H]QNB binding in the frontal cortex and hippocampus compare with the vehicle-treated aged animals. Also, chronic treatment with Vinconate at the higher dose significantly elevates [3H]QNB binding in the hippocampal CA3 sector and dentate gyrus compare with the vehicle-treated aged animals. Chronic treatment with Vinconate at a dose of 10 mg/kg shows a significant reduction in [3H]HC binding only in the hippocampal CA1 sector compare with the vehicle-treated aged rats[2].
References
[1] Iino T, et al. Effect of vinconate, an indolonaphthyridine derivative, on dopamine and serotonin concentrations in dialysate from the striatum of freely moving rats: brain microdialysis studies. J Pharmacol Exp Ther. 1996 Aug;278(2):614-9. PMID:8768711
[2] Araki T, et al. Effects of vinconate on neurotransmitter receptor systems in aged rat brain. Environ Toxicol Pharmacol. 1996 Dec 20;2(4):343-9. DOI:10.1016/s1382-6689(96)00068-3
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