LY 294002 Chemical Properties

storage temp. 

2-8°C

solubility 

DMSO: >5mg/mL

form 

solid

color 

white to off-white

biological source

microbial (Staphylococcus roseus)

Safety Information

WGK Germany 

3

HS Code 

29349990

LY 294002 Usage And Synthesis

Uses

LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590).

General Description

LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.

Biological Activity

Specific cell permeable phosphatidylinositol 3-kinase inhibitor.

storage

Room temperature