Pirinixil
Pirinixil Basic information
- Product Name:
- Pirinixil
- Synonyms:
-
- 2-[[4-Chloro-6-(2,3-dimethylphenylamino)-2-pyrimidinyl]thio]-N-(2-hydroxyethyl)acetamide
- 2-[[4-Chloro-6-[(2,3-dimethylphenyl)amino]pyrimidin-2-yl]thio]-N-(2-hydroxyethyl)acetamide
- Pirinixil
- Acetamide, 2-[[4-chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]-N-(2-hydroxyethyl)-
- CAS:
- 65089-17-0
- MF:
- C16H18ClN3OS
- MW:
- 366.87
- Mol File:
- 65089-17-0.mol
Pirinixil Chemical Properties
- Melting point:
- 145°C
- Boiling point:
- 609.6±55.0 °C(Predicted)
- Density
- 1.2894 (rough estimate)
- refractive index
- 1.6100 (estimate)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 13.27±0.46(Predicted)
Pirinixil Usage And Synthesis
Uses
Pirinixil, is an absorbable hypolipidemic agent of low toxicity.
Safety Profile
Suspected carcinogen with experimental carcinogenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl-, NOx and SOx
in vivo
Pirinixil is a hypolipidemic agent of low toxicity. Total cholesterol is reduced by Pirinixi in the spleen, kidney and heart of rats. Pirinixil decreases the estimated total body cholesterol approximately 40%[1]. Pirinixil increases plasma cholesterol levels significantly without affecting plasma triglycerides. Liver cholesterol and triglycerides are markedly reduced by Pirinixil, while combined plasma and liver lipid levels decrease approximately 20%. Liver HMG-CoA reductase activity is not affected, but cholesterol 7α-hydroxylase is significantly reduced by Pirinixil[2].
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