Dactylfungin B Usage And Synthesis

Description

Dactylfungin B is isolated from Dactylaria parvispora. Dactylfungins are novel antifungal antibiotics produced by Dactylaria parvispora. Novel antifungal antibiotics, designated as dactylfungins A (1) and B (3), were isolated from the culture broth of Dactylaria parvispora D500. Dactylfungins A and B were found to be new substances containing an alpha-pyrone and a gamma-pyrone ring, respectively, which conjoined with a polyalcohol moiety and a long side chain, based on NMR spectral analyses. The antibiotics were active against Candida pseudotropicalis and other fungi, with an MIC value at less than 10 micrograms/ml.

Uses

Dactylfungin B (MK 2266 B) is an antifungal antibiotic that is active against Candida pseudotropicalis and other fungi, with an MIC value at <10 μg/mL[1].

References

[1] J Xaio, et al. Dactylfungins, novel antifungal antibiotics produced by Dactylaria parvispora. J Antibiot (Tokyo). 1993 Jan;46(1):48-55. DOI:10.7164/antibiotics.46.48

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