3-FLUORO-4-METHOXYBENZYLAMINE Chemical Properties

Boiling point:

234.9±25.0 °C(Predicted)

Density 

1.127±0.06 g/cm3(Predicted)

refractive index 

1.5280

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

9.04±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

Water Solubility 

Immiscible with water.

Sensitive 

Air Sensitive

Safety Information

RIDADR 

UN2735

HazardClass 

8

PackingGroup 

III

HS Code 

2922290090

3-FLUORO-4-METHOXYBENZYLAMINE Usage And Synthesis

Uses

3-Fluoro-4-methoxybenzylamine is used as an intermediate in organic synthesis.

Synthesis

Example 2.1.1: Preparation of (3-fluoro-4-methoxyphenyl) methylamine (ICb). To a solution of 3-fluoro-4-methoxybenzyl cyanide (ICa, 68.0 g, 450 mmol, 1 equiv) in methanol (2 L) was added Raney nickel (Raney-Ni, 70.0 g). After addition, the reaction mixture was stirred at room temperature overnight. After completion of the reaction, the solid formed was removed by filtration and the solid was washed with methanol. The clarified filtrate was concentrated under reduced pressure to afford the title compound (3-fluoro-4-methoxyphenyl)methylamine (ICb, 62.8 g, 90% yield) as a yellow oil.

References

[1] Patent: WO2015/127137, 2015, A1. Location in patent: Page/Page column 148

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