FOY 251
FOY 251 Basic information
- Product Name:
- FOY 251
- Synonyms:
-
- FOY 251
- 4-(4-guanidinobenzoyloxy)phenylacetic acid
- 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]-benzeneacetic Acid Monomethanesulfonate
- 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]-benzeneacetic Acid Monomethanesulfonat
- FOY 251（Camostat metabolite）
- FOY-251 mesylate
- 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt
- Benzeneacetic acid,4-[[4-[(aminoiminomethyl)- amino]benzoyl]oxy]-,monomethanesulfonate
- CAS:
- 71079-09-9
- MF:
- C17H19N3O7S
- MW:
- 409.41
- Product Categories:
-
- Amine
- Aromatics
- Chemical Amines
- Inhibitors
- Metabolites & Impurities
- Mol File:
- 71079-09-9.mol
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FOY 251 Chemical Properties
- Melting point:
- 194-198°C
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- Water: < 0.1 mg/mL (insoluble)
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FOY 251 Usage And Synthesis
Chemical Properties
White Solid
Uses
A metabolite of Camostat. It is a pollen protease inhibitor for prevention and control of allergy.
Biological Activity
Trypsin-like serine protease inhibitor Camost at (FOY-305) active metabolite with inhibitory potency against transmembrane serine protease 2 (TMPRSS2).
FOY-251 is a trypsin-like serine protease inhibitor and an active metabolite of the oral drug Camostat/FOY-305 (trypsin IC50 = 51/55 nM by FOY-305/FOY-251; plasma kallikrein/plasmin IC50 = 1.48/2.64 μM by FOY-305 and 2.32/12.5 μM by FOY-251). FOY-251 and FOY-305 are also potent inhibitor against transmembrane serine protease 2 (TMPRSS2 IC50 = 6.2/33.3 nM by by FOY-305/FOY-251) th at primes SARS-CoV-2 spike protein for host cell entry.
FOY 251Supplier
J & K SCIENTIFIC LTD.
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