Midaglizole
Midaglizole Basic information
- Product Name:
- Midaglizole
- Synonyms:
-
- 2-[2-(2-Imidazolin-2-yl)-1-phenylethyl]pyridine
- 4,5-Dihydro-2-[2-(2-pyridinyl)-2-phenylethyl]-1H-imidazole
- DG-5128
- Midaglizole
- Pyridine, 2-[2-(4,5-dihydro-1H-imidazol-2-yl)-1-phenylethyl]-
- DG5128 free base
- (±)-DG5128 free base|||DG5128 free base|||(±)-DG5128 free base
- CAS:
- 66529-17-7
- MF:
- C16H17N3
- MW:
- 251.33
- Mol File:
- 66529-17-7.mol
Midaglizole Chemical Properties
- storage temp.
- Store at -20°C
- form
- Solid
- color
- White to off-white
Midaglizole Usage And Synthesis
Uses
Midaglizole ((±)-DG5128 free base, DG5128 free base) is a potent α2-adrenoceptor antagonist. Midaglizole is a hypoglycemic agent. Midaglizole increases blood pressure and reduces blood glucose levels in vivo[1][2][3].
in vivo
Midaglizole (3, 30 mg/kg; i.v.) increases blood pressure in rats[1].
Midaglizole (0.2, 1, 2 mg/kg; infusion) reduces blood glucose levels in dags[2].
| Animal Model: | 290-450 g, Male Wistar rats[1] |
| Dosage: | 3, 30 mg/kg |
| Administration: | I.v. |
| Result: | Increased the blood pressure by 27 and 64 mmHg at 3, 30 mg/kg, respectively. |
| Animal Model: | Dogs[2] |
| Dosage: | 0.2, 1, 2 mg/kg |
| Administration: | Superior pancreaticoduodeneal artery infusion |
| Result: | Reduced blood glucose levels by stimulating insulin release from the pancreatic islets. |
References
[1] Hirohashi M, et al. Intrinsic pressor activity of midaglizole, an alpha-2 adrenoceptor antagonist, in pithed rats. Jpn J Pharmacol. 1990 Aug;53(4):519-20. DOI:10.1254/jjp.53.519
[2] Ohneda K, et al. Mechanism of insulin secretion by midaglizole. Diabetes Res Clin Pract. 1993 Feb;19(2):127-32. DOI:10.1016/0168-8227(93)90105-e
[3] Proks P, et al. Inhibition of recombinant K(ATP) channels by the antidiabetic agents midaglizole, LY397364 and LY389382. Eur J Pharmacol. 2002 Sep 27;452(1):11-9. DOI:10.1016/s0014-2999(02)02234-3