AIDS124653
AIDS124653 Basic information
- Product Name:
- AIDS124653
- Synonyms:
-
- AIDS124653
- 1-(5-Methyl-2-thienyl)-3-phenyl-2-Propen-1-one
- 1-(5-Methyl-thiophen-2-yl)-3-phenyl-propenone
- NSC 43067
- NSC43067
- NSC43067 >=98% (HPLC)
- 2-Propen-1-one, 1-(5-methyl-2-thienyl)-3-phenyl-
- CAS:
- 26903-26-4
- MF:
- C14H12OS
- MW:
- 228.31
- Mol File:
- 26903-26-4.mol
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AIDS124653 Chemical Properties
- Boiling point:
- 379.8±42.0 °C(Predicted)
- Density
- 1.167±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >20mg/mL
- form
- powder
- color
- light yellow to light tan
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AIDS124653 Usage And Synthesis
Biochem/physiol Actions
NSC43067 is a Cyclin-dependent kinase (Cdk) inhibitor which binds to a novel conserved site on Cdk, presumably the p27 binding pocket. The binding apparently directly induces Cdk1, Cdk2, and Cdk4 protein aggregation. Cdks 1, 2, 4, and 6 are the key Cdks that regulate the cell cycle, and are a target for a cancer treatment. NSC43067 arrests the cell cycle at the G0/G1 phase at lower concentrations and at the G2/M cell cycle phase at higher concentrations. The action appears to be reversible.